As Tribal healthcare workers, Tribal health systems administrators, and Infection Preventionists (IP) monitor the emergence of new Variants of Concern (VOC) of SARS-CoV-2, such as Omicron, it is important to continue to monitor all variants. National Indian Health Board’s (NIHB) Project Firstline (PFL) partners at the Centers for Disease Control and Prevention (CDC) have released a new video with information on the Delta variant of SARS-CoV-2. Watch the video HERE to learn more about how virus variants develop. PFL also has several resources for Tribal healthcare workers to learn more about the Delta variant and what it means for infection control in Tribal healthcare. The resources HERE include information about source control in healthcare, how variants spread, and recommendations for infection control. Tribal healthcare workers interested in receiving email updates when a variant classification or definition changes can sign up with the CDC Variant Classification and Definitions webpage. Updates about the new variants will be provided as information becomes available.